New DNA Analysis Says Your Pooch’s Ancestors Were Central Asian Wolves
Dogs' origin story goes something like this: sometime between 16,000 and 30,000 years ago, there were some stressed-out hungry wolves whose hunting territory had been encroached upon by humans....
View ArticleDogs May Have Originated In Central Asia
Researchers analyzing the DNA of over 5,000 purebreds and mixed breeds alike say dogs were domesticated in Central Asia – likely near modern-day Nepal or Mongolia – and then they spread from there to...
View ArticleGenetic structure in village dogs reveals a Central Asian domestication origin
Abstract Dogs were the first domesticated species, originating at least 15,000 y ago from Eurasian gray wolves. Dogs today consist primarily of two specialized groups—a diverse set of...
View ArticleGolden jackal: A new wolf species hiding in plain sight
A new species of wolf has been discovered in Africa after exhaustive DNA and morphological analyses revealed it is evolutionarily distinct from the Eurasian golden jackal, which it strongly resembles...
View ArticleMiddle East's key role in dogs' evolution
Characterised by their elegant, slim bodies, long legs and hairy ears, salukis are among the most iconic animals of the Middle East. These sighthounds - hunting by sight rather then scent - have been...
View ArticleIncreased Power To Dissect Adaptive Traits in Global Sorghum Diversity Using...
Abstract Adaptation of domesticated species to diverse agroclimatic regions has led to abundant trait diversity. However, the resulting population structure and genetic heterogeneity confounds...
View ArticleGenomes of the Mouse Collaborative Cross [Investigations]
Abstract The Collaborative Cross (CC) is a multiparent panel of recombinant inbred (RI) mouse strains derived from eight founder laboratory strains. RI panels are popular because of their long-term...
View ArticleWheat Landrace Genome Diversity [Genetics of Complex Traits]
Abstract Understanding the genomic complexity of bread wheat (Triticum aestivum L.) is a cornerstone in the quest to unravel the processes of domestication and the following adaptation of domesticated...
View ArticleDogs Originated in Central Asia
Genetic studies have previously indicated that dogs were first domesticated in China, but the fossil record points to possible origins in Europe and Siberia. Researchers from Cornell University in...
View ArticleRole of Ectopic Gene Conversion in the Evolution of a Candida krusei...
Abstract Gene duplications enable the evolution of novel gene function, but strong positive selection is required to preserve advantageous mutations in a population. This is because frequent ectopic...
View ArticleThe Hippo Pathway Maintains the Equatorial Division Plane in the Ciliate...
Abstract The mechanisms that govern pattern formation within the cell are poorly understood. Ciliates carry on their surface an elaborate pattern of cortical organelles that are arranged along the...
View ArticleGenetic Architecture of Phenomic-Enabled Canopy Coverage in Glycine max...
Abstract Digital imagery can help to quantify seasonal changes in desirable crop phenotypes that can be treated as quantitative traits. Because limitations in precise and functional phenotyping...
View ArticleSharing of Genes and Pathways Across Complex Phenotypes: A Multilevel...
Abstract Evidence from genome-wide association studies (GWAS) suggest that pleiotropic effects on human complex phenotypes are very common. Recently, an atlas of genetic correlations among complex...
View ArticleCLEAR: Composition of Likelihoods for Evolve and Resequence Experiments...
Abstract The advent of next generation sequencing technologies has made whole-genome and whole-population sampling possible, even for eukaryotes with large genomes. With this development, experimental...
View ArticleThe Nucleoporin Nup2 Contains a Meiotic-Autonomous Region that Promotes the...
Abstract Meiosis is a specialized cellular program required to create haploid gametes from diploid parent cells. Homologous chromosomes pair, synapse, and recombine in a dynamic environment that...
View ArticleInference of Gene Flow in the Process of Speciation: An Efficient...
Abstract The isolation-with-migration (IM) model is commonly used to make inferences about gene flow during speciation, using polymorphism data. However, it has been reported that the parameter...
View ArticleThe Mouse Lemur, a Genetic Model Organism for Primate Biology, Behavior, and...
Abstract Systematic genetic studies of a handful of diverse organisms over the past 50 years have transformed our understanding of biology. However, many aspects of primate biology, behavior, and...
View ArticleBenchmarking Relatedness Inference Methods with Genome-Wide Data from...
Abstract Inferring relatedness from genomic data is an essential component of genetic association studies, population genetics, forensics, and genealogy. While numerous methods exist for inferring...
View ArticleModel Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research...
Abstract Efforts to identify the genetic underpinnings of rare undiagnosed diseases increasingly involve the use of next-generation sequencing and comparative genomic hybridization methods. These...
View ArticlePathways and Mechanisms that Prevent Genome Instability in Saccharomyces...
Abstract Genome rearrangements result in mutations that underlie many human diseases, and ongoing genome instability likely contributes to the development of many cancers. The tools for studying genome...
View ArticleExperimental Evolution Reveals Favored Adaptive Routes to Cell Aggregation in...
Abstract Yeast flocculation is a community-building cell aggregation trait that is an important mechanism of stress resistance and a useful phenotype for brewers; however, it is also a nuisance in many...
View ArticleNeutral Competition for Drosophila Follicle and Cyst Stem Cell Niches...
Abstract The process of selecting for cellular fitness through competition plays a critical role in both development and disease. The germarium, a structure at the tip of the ovariole of a Drosophila...
View ArticleThe Mitotic Exit Network Regulates Spindle Pole Body Selection During...
Abstract Age-based inheritance of centrosomes in eukaryotic cells is associated with faithful chromosome distribution in asymmetric cell divisions. During Saccharomyces cerevisiae ascospore formation,...
View ArticleA New History of the First Peoples in the Americas
Europeans arriving in the New World met people all the way from the frozen north to the frozen south. All had rich and mature cultures and established languages. The Skraeling were probably a people we...
View ArticleExact Calculation of the Joint Allele Frequency Spectrum for Isolation with...
Abstract Population genomic datasets collected over the past decade have spurred interest in developing methods that can utilize massive numbers of loci for inference of demographic and selective...
View ArticleMeiotic Consequences of Genetic Divergence Across the Murine Pseudoautosomal...
Abstract The production of haploid gametes during meiosis is dependent on the homology-driven processes of pairing, synapsis, and recombination. On the mammalian heterogametic sex chromosomes, these...
View ArticleNetworks Underpinning Symbiosis Revealed Through Cross-Species eQTL Mapping...
Abstract Organisms engage in extensive cross-species molecular dialog, yet the underlying molecular actors are known for only a few interactions. Many techniques have been designed to uncover genes...
View ArticleMobile Introns Shape the Genetic Diversity of Their Host Genes [Population...
Abstract Self-splicing introns populate several highly conserved protein-coding genes in fungal and plant mitochondria. In fungi, many of these introns have retained their ability to spread to...
View ArticleComplex Coding and Regulatory Polymorphisms in a Restriction Factor Determine...
Abstract It is common to find that major-effect genes are an important cause of variation in susceptibility to infection. Here we have characterized natural variation in a gene called pastrel that...
View ArticleLIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational...
Abstract An extended meiotic prophase is a hallmark of oogenesis. Hormonal signaling activates the CDK1/cyclin B kinase to promote oocyte meiotic maturation, which involves nuclear and cytoplasmic...
View ArticleWhole-Genome Restriction Mapping by "Subhaploid"-Based RAD Sequencing: An...
Abstract Assembly of complex genomes using short reads remains a major challenge, which usually yields highly fragmented assemblies. Generation of ultradense linkage maps is promising for anchoring...
View ArticleX-Chromosome Control of Genome-Scale Recombination Rates in House Mice...
Abstract Sex differences in recombination are widespread in mammals, but the causes of this pattern are poorly understood. Previously, males from two interfertile subspecies of house mice, Mus musculus...
View ArticleResolving the Complex Genetic Basis of Phenotypic Variation and Variability...
Abstract In all organisms, the majority of traits vary continuously between individuals. Explaining the genetic basis of quantitative trait variation requires comprehensively accounting for genetic and...
View ArticleIdentification of Ceruloplasmin as a Gene that Affects Susceptibility to...
Abstract Crescentic glomerulonephritis (Crgn) is a complex disorder where macrophage activity and infiltration are significant effector causes. In previous linkage studies using the uniquely...
View ArticleEstimating Seven Coefficients of Pairwise Relatedness Using...
Abstract Population structure can be described by genotypic-correlation coefficients between groups of individuals, the most basic of which are the pairwise relatedness coefficients between any two...
View ArticleEpistatic Networks Jointly Influence Phenotypes Related to Metabolic Disease...
Abstract Genetic studies of multidimensional phenotypes can potentially link genetic variation, gene expression, and physiological data to create multi-scale models of complex traits. The challenge of...
View ArticleBuilding Ultra-High-Density Linkage Maps Based on Efficient Filtering of...
Abstract The study is focused on addressing the problem of building genetic maps in the presence of ∼103–104 of markers per chromosome. We consider a spectrum of situations with intrachromosomal...
View ArticleNaturally Segregating Variation at Ugt86Dd Contributes to Nicotine Resistance...
Abstract Identifying the sequence polymorphisms underlying complex trait variation is a key goal of genetics research, since knowing the precise causative molecular events allows insight into the...
View ArticleGenomic Rearrangements in Arabidopsis Considered as Quantitative Traits...
Abstract To understand the population genetics of structural variants and their effects on phenotypes, we developed an approach to mapping structural variants that segregate in a population sequenced...
View ArticleA Unified Characterization of Population Structure and Relatedness...
Abstract Many population genetic activities, ranging from evolutionary studies to association mapping, to forensic identification, rely on appropriate estimates of population structure or relatedness....
View ArticleStructure and Origin of the White Cap Locus and Its Role in Evolution of...
Abstract Selection for yellow- and white-grain types has been central to postdomestication improvement of maize. While genetic control of carotenoid biosynthesis in endosperm is attributed primarily to...
View ArticleTracing Genetic Exchange and Biogeography of Cryptococcus neoformans var....
Abstract Cryptococcus neoformans var. grubii is the causative agent of cryptococcal meningitis, a significant source of mortality in immunocompromised individuals, typically human immunodeficiency...
View ArticleThe Recombination Landscape in Wild House Mice Inferred Using Population...
Abstract Characterizing variation in the rate of recombination across the genome is important for understanding several evolutionary processes. Previous analysis of the recombination landscape in...
View ArticleThe Natural Biotic Environment of Caenorhabditis elegans [Evolution and Ecology]
Abstract Organisms evolve in response to their natural environment. Consideration of natural ecological parameters are thus of key importance for our understanding of an organism’s biology. Curiously,...
View ArticleInferring the Joint Demographic History of Multiple Populations: Beyond the...
Abstract Understanding variation in allele frequencies across populations is a central goal of population genetics. Classical models for the distribution of allele frequencies, using forward...
View ArticleThe Genomic Architecture of Flowering Time Varies Across Space and Time in...
Abstract The degree to which genomic architecture varies across space and time is central to the evolution of genomes in response to natural selection. Bulked-segregant mapping combined with pooled...
View ArticleExperimental Evolution with Caenorhabditis Nematodes [Evolution and Ecology]
Abstract The hermaphroditic nematode Caenorhabditis elegans has been one of the primary model systems in biology since the 1970s, but only within the last two decades has this nematode also become a...
View ArticleGenome Diversity and Evolution in the Budding Yeasts (Saccharomycotina)...
Abstract Considerable progress in our understanding of yeast genomes and their evolution has been made over the last decade with the sequencing, analysis, and comparisons of numerous species, strains,...
View ArticleMolecular Population Genetics [Ecology and Evolution]
Abstract Molecular population genetics aims to explain genetic variation and molecular evolution from population genetics principles. The field was born 50 years ago with the first measures of genetic...
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